This research focuses on developing a detailed finite element model of a rat's head and brain to better understand the mechanics of blast-induced traumatic brain injuries. Using high-resolution MRI and CT scans, we created a 3D model which incorporated five major internal brain structures. This model, subjected to a realistic shockwave, allowed us to study strain, pressure, and internal energy. Using extensive literature review and sensitivity analysis, we established ideal material properties for the rat brain under high strain rates. Our model's validity was confirmed by matching simulated intracranial pressure profiles with experimental results. This research provides a valuable tool for exploring the correlation between mechanical stress on specific brain regions and blast-induced traumatic brain injuries.
Skills Demonstrated
Medical image Processing: 3D model generation via compilations of MRI brain scans
FEA Simulation: Testing with set boundary conditions
3D printing: Microscope slide holders, objects for rat behavior studies
Research: Literature review on TBI affected regions of brain
CONFERENCE PROCEEDINGS:
Debrina Roy, Molly Townsend, et al., Developing and Validating a Finite Element Rat Model for Investigating Blast-Induced Traumatic Brain Injury, Institute for Brain & Neuroscience Research (IBNR), E-Poster Session, NJIT-RUTGERS, 2018.